What is Cerenia 10 mg/ml Injectable Solution?

Cerenia 10 mg/ml Solution for Injection is a highly effective, broad-spectrum veterinary antiemetic designed to prevent and treat acute vomiting (emesis) and nausea in both dogs and cats. Powered by maropitant (as maropitant citrate monohydrate), this prescription-grade injectable solution acts directly on the central nervous system to stop vomiting at its source, offering superior control compared to traditional antiemetics.

Each 20 ml multi-dose amber glass vial contains a clear, colorless to pale yellow sterile solution, making it an essential treatment option for veterinary clinics and hospital settings.

How Does It Work?

Maropitant is a potent and selective neurokinin-1 ($NK_1$) receptor antagonist. It works by blocking the binding of substance P—a key neuropeptide neurotransmitter concentrated in the emetic center of the brain that triggers the vomiting reflex. By targeting this final common pathway, Cerenia effectively controls vomiting triggered by both central (neurological) and peripheral (humoral/visceral) pathways.

Key Benefits and Clinical Indications

• Rapid Control of Acute Vomiting: Fast-acting relief from severe vomiting associated with gastroenteritis, pancreatitis, systemic infections (such as canine parvovirus), or metabolic disorders.

• Prevention of Post-Operative Nausea: When administered pre-anesthetically, Cerenia significantly reduces perioperative nausea and vomiting induced by emetogenic pre-medications (such as opioids like morphine), leading to a smoother, safer recovery from anesthesia.

• Chemotherapy-Induced Vomiting Management: Prevents severe nausea and vomiting in dogs undergoing cancer treatments, preserving their appetite and overall quality of life.

• Non-Sedative Action: Unlike older generation antiemetics, Cerenia does not cause drowsiness, allowing pets to remain alert during recovery.

Dosage and Administration Guide

Cerenia Solution for Injection should be administered subcutaneously (SC) or intravenously (IV).

• Standard Dose: The recommended dosage is 1 mg of maropitant per kg of body weight (equivalent to 0.1 ml of solution per kg of body weight), administered once daily.

• Duration: Can be administered for up to 5 consecutive days.

• Pro Tip: For subcutaneous injections, storing the vial in the refrigerator prior to use and injecting it cold significantly reduces the temporary stinging or discomfort at the injection site.

Important Safety and Precautions

⚠️ Prescription Only: Cerenia is a prescription-only veterinary medicine. Do not use this product if a gastrointestinal obstruction is suspected or if the animal has ingested toxic substances.

• Use with caution in pets with impaired liver function or pre-existing cardiac conditions, as maropitant is metabolized by the liver.

• The safety of this product has not been fully evaluated in pregnant or lactating animals.

• Storage: Once the vial is broached for the first time, store it refrigerated ($2\text{--}8^\circ\text{C}$) and use within 90 days. Keep out of reach of children.